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ISICEM 2015 - Blog

adrian Follow @avkwong

Author: Adrian Wong - Clinical Fellow ICM/Echo Oxford Deanery
Edited by:
Steve Mathieu

ISICEM 2015 18/3/15 – DAY 1
International Symposium on Intensive Care & Emergency Medicine in Brussels

Opening Plenary Session

Say YES to intensive care (J-L Vincent)
Setting the tone on the 35th anniversary of the ISICEM meeting

In the last 35 years, as a specialty, we are doing less and less e.g. transfusion, fluids, tidal volumes.

A cautionary note on the endless pursuit of EBM via RCTs. There are a lot of ‘negative’ RCTs (I personally hate the term ‘negative’ trials. It plays done the huge effort put in by the research team). Patients on the ICU are very heterogenous and hence are we surprised that one size doesn’t fit all?

Perhaps a more positive view point is the fact that although mortality is static, the age of our patient has increased. The burden of ICU care should not be underestimated. Patients may benefit from earlier intervention rather than banging on death’s door before being admitted. Accessibility to ICU care needs to be timely.

Closing note – realise the difference between protocolised care vs intelligent care.

Reducing the global burden of sepsis (S Finfer)

Highlights from the roundtable discussion on understanding the burden of sepsis in the global context.

Areas to be tackled

  • Understanding its epidemiology. Data is scarce from countries in Africa and Asia. Global Burden Of Disease Study - http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61682-2/abstract
  • The impact of our changing world on the disease
- Global warming
- Ageing population
- More mobile population/Urbanisation
- Antibiotic resistance
  • Measures to manage sepsis
- Prevent ICU-acquired sepsis
- CVS optimisation
- Infection control
- Modulation of sepsis response
  • Morbidity the price of success

With improved data we can also improve awareness among health care workers, the public and politicians (World Sepsis Day 13th Sept)

Sepsis success:
1 Reducing case fatality rates in many countries
2 World Sepsis Day and increasing awareness
3 Hand hygiene and prevention initiatives
4 High quality investigator initiated research
5 International/global collaboration on many fronts

What did you ProMISe? (K Rowan) LINK

The last in the trilogy of EGDT trial.


Primary outcome
• No difference in all cause mortality at 90 days in EGDT vs usual care (29.5% vs 29.2%)
Secondary outcome
• SOFA score at 6 hours and 72 hours: higher SOFA scores in EGDT but that is due to intervention
• Receipt of organ support in critical care: More CVS support in EGDT
• Duration of organ support in critical care: No difference
• Duration of stay: No difference
• All cause mortality: No difference at 28 days, hospital discharge and at 1 year
Pooled data (Protocolised Resuscitation in Sepsis individual patient data Meta-analysis) – NO DIFFERENCE IN 90 DAY MORTALITY

In adults, presenting to ED with signs of early septic shock, identified early and receiving IV antibiotics and adequate fluid resuscitation – haemodynamic management according to a strict EGDT protocol does not lead to an improvement in outcome.

Transfusion - does the age of RBC matter? (P Herbert) LINK

Fresh (less than 8 days) RBCs vs standard RBCs in order to improve 90 day mortality and morbidity
Fresh red cells do not appear to be superior to standard issue red cells in critically ill patients

SIRS is dead (R Bellomo) LINK

The original definitions of SIRS/Sepsis are now more than 20 years old
Problems with the definition:
  • Terminology does not help us understand the underlying problem
  • SIRS is too sensitive but is not specific
  • SIRS does not reflect the severity of the disease process
  • SIRS may detract from the search for infection
82.2% of ICU patients without infection have ‘SIRS’
Patients can have severe sepsis without SIRS i.e. limited sensitivity and yet they have features of major illness
There is no step-up in risk at having 2 SIRS criteria compared to 3 or 4 – lack construct validity

Sepsis 3.0 (Singer)

Host response is key
Sepsis is not simply a systemic inflammatory response
Variety of anti-inflammatory and other (mal)adaptive responses occur concurrently
Sepsis should be defined as life-threatening organ dysfunction due to a dysregulated host response to infection
Sepsis = really sick infection
No definition is data driven using SOFA score to characterised organ dysfunction
SOFA superior in ICU but poor on ward and ED.
qSOFA – altered mental status, respiratory rate and systolic BP is superior on ward and ED

Personalised medicine in the future (H Wong)
Precision Medicine Initiative - http://www.nih.gov/precisionmedicine/
ICM deals with syndromes and hence needs personalised care
Current diagnostic tests to define subclasses/endotypes of critical illness are too slow
Future would involve multiplate mRNA testing to allow customise therapy based on biologically-defined endotypes

Should we centralise ICU care?

Advantages and problems (D Angus)

Existing critical care

  • Expensive, poorly distributed and stretched thin
  • Care May be better at larger centres
  • Regionalised trauma systems demonstrate potential
  • But, critical care is more complex than trauma
  • Regionalising critical care: Potential benefits; Some aspects are not that hard, once incentives aligned
  • Demonstrate projects
  • Regional centres
  • Telemedicine
  • Community/Interhospital outreach
  • Hybrids
  • Areas of future research: Reasons for volume outcomes; Alternative staffing models

ECMO Centres (A Combes)
  • Only experienced centres should run ECMO programmes
  • Both VA and VV ECMO, at least 20 cases per year
  • Create regional networks of hospitals
  • Detect early refractory cardiac/respiratory failure
  • Mobile ECMO retrieval tams in all ECMO centres 24/7

Trauma Centres (O Grottke)
Probably the most established regionalised/centralised service
Right patient at the right place at the right time for the right treatment
Benefits have been replicated in studies across the globe

Cardiac arrest centres (J Nolan)
Aim is to maximise myocardial and neurological recovery
PROCAT Registry (
http://www.ncbi.nlm.nih.gov/pubmed/20484098) In OHCA patients with no obvious extra-cardiac cause, a significant proportion will have abnormal coronaries found at angiography.
Prognostication post cardiac arrest -
Logical progression of existing regionalisation
24/7 access to cardiac cath lab
Comprehensive post-resuscitation care
Neurological support for prognostication: SSEP, NSE, continuous EEG
Indirect evidence for better outcomes
It’s happening anyway!

Early resuscitation is sepsis

What do you mean by early (J Bakker)
Earlier is better
Defibrillation in cardiac arrest - http://www.nejm.org/doi/full/10.1056/NEJMoa0706467
Antibiotics - http://www.ncbi.nlm.nih.gov/pubmed/16625125
Early admission to ICU - http://www.ncbi.nlm.nih.gov/pubmed/17167350

The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: a meta-analysis of randomized controlled trials LINK

Targeting blood pressure (JL Teboul)
Hemodynamic variables related to outcome in septic shock - http://link.springer.com/article/10.1007/s00134-005-2688-z
Use vasopressors even when hypovolaemia has not been completely resolved
Target higher BP if
Normally hypertensive
Elevated CVP
Increased abdominal pressure


Still a place for transfusion (A Perner)
More pts transfused in EGDT vs usual care groups –
PROCESS – 14 vs 8%
ARISE – 14 vs 7%
Rivers 64 vs 19%

unknown TRISS

How to prevent renal failure (R Bellomo)
Preventing AKI in sepsis
Do not give starch
Do not give gelatin
Do not give NSAIDs
Do not give multiple doses of aminoglycosides
Do not give long courses of vancomycin
Do not give amphotericin
Consider giving chloride-poor or chloride physiologic fluids
In septic patients renal protection remains elusive
Avoid nephrotoxins
Probably best to maintain a MAP close to basal night-time levels
Avoid fluid overload
Consider vasopressin
Consider global (patient) costs
Killing the patient while trying to save the kidney is not a good idea

Improving sepsis performance in the ED (F Machado)
Describe the challenges of implement a change in practice in the ED with regards to sepsis management
Key – multifaceted approach to get people to do what they agree to do e.g. education, training, incentives, etc.

Improving sepsis performance on the ward (R Dellinger)
Quality improvement project to roll out SSC bundles on the wards in a US hospital
Nurses empowered, electronic notes/warning systems
Pharmacist ensures antibiotics are administered within 15 minutes of being prescribed

The essential haemodynamic variables

Interpretation of heart rate (A Morelli)
Tachycardia can be compensatory or non-compensatory
Compensatory mechanisms are only useful over a short time frame

unknown Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock A Randomized Clinical Trial]

Arterial pressure (S Magdar)
Step 1 – observe patient. If patient is fully awake, communicating, good colour, urinating, normal BE/lactate, their BP is likely to be adequate. Observe

  • We are pressure regulated species – arterial pressure is relatively constant under normal conditions
  • Volume and compliance determine the pressure
  • CO and SVR determine the central pressure. Central pressure determines the regional flow.
  • Total energy NOT pressure determines flow – gravitational, elastic and kinetic

CVP (M Cecconi)
FENICE Trial Protocol - http://www.esicm.org/upload/Protocol_FENICE07_11_2012Final.pdf
Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense.
CVP is an important variable as it is key determinant of venous return
Best interpreted when look at: Changes CVP; Concomitant changes in CO

How to measure pressure accurately (JL Teboul)
How to measure pressure accurately (JL Teboul)
Errors in CVP measurement -
Sources of error
Inappropriate zero point (anatomical)
CVP measured at the foot of c wave
CVP and PAOP are measured at end-expiration – will thus depend on SV or IPPV
Subtract the estimated PEEP/auto PEEP

How to measure cardiac output accurately (X Monnet)
Dilution techniques are accurate and should replace PA catheters as the goal standard
Uncalibrated pulse contour analysis
SV proportional to amplitude of aortic pressure
Relationship is influenced by vascular compliance and resistance. Hence are unreliable in case of changes in vasoactive tone
Volume clamp method e.g. NEXFIN are not very accurate in the ICU setting
CO is not regional blood flow, nor tissue perfusion, but only a part of it

Blogs for day 2 and 3 of the conference can be found on the OXICM Blog - click links below

oxicmblog1-e1425844577434 ISICEM 2015 BLOG DAY 2

oxicmblog1-e1425844577434 ISICEM 2015 BLOG DAY 3